中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (18): 1428-1435.

• 原著:退行性病与再生 • 上一篇    下一篇

Five-year follow-up of 23 asymmetrical Parkinson’s disease patients treated with unilateral subthalamic nucleus stimulation

  

  • 收稿日期:2012-01-08 修回日期:2012-04-23 出版日期:2012-06-25 发布日期:2012-06-25

Five-year follow-up of 23 asymmetrical Parkinson’s disease patients treated with unilateral subthalamic nucleus stimulation

Jinchuan Liang1, Xiaowu Hu1, Xiaoping Zhou1, Xiufeng Jiang1, Yiqun Cao1, Laixing Wang1,  Aiguo Jin2, Jianmin Liu1   

  1. 1  Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China
    2  Department of Radiology, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China
  • Received:2012-01-08 Revised:2012-04-23 Online:2012-06-25 Published:2012-06-25
  • Contact: Xiaowu Hu, Master, Professor, Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China huxiaowu25@sina.com
  • About author:Jinchuan Liang★, Master, Physician, Department of Neurosurgery, Changhai Hospital of the Second Military Medical University of Chinese PLA, Shanghai 200433, China

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Abstract:

In this study, 23 asymmetrical Parkinson’s disease patients were treated with unilateral deep brain stimulation of the subthalamic nucleus and followed up for 5 years. At 5 years after stimulation treatment, Unified Parkinson’s Disease Rating Scale II, III and axial symptom scores in the off-drug condition were significantly increased compared those at baseline. However, total Unified Parkinson’s Disease Rating Scale II, III and axial symptom scores were significantly lower with stimulation-on compared with the synchronous stimulation-off state in off-drug condition, and the motor symptoms of contralateral side limbs were effectively controlled. Only low Hoehn-Yahr stage was correlated with good long-term postoperative improvement in motor symptoms. The mean levodopa-equivalent daily dose after stimulation treatment was significantly lower than that before treatment, but dyskinesias became worse. Our experimental findings indicate that unilateral deep brain stimulation of the subthalamic nucleus is an effective treatment for improving motor symptoms in well selected asymmetrical Parkinson’s disease patients presenting no severe axial symptoms and dyskinesias.

Key words: Parkinson’s disease, deep brain stimulation, subthalamic nucleus, neural regeneration