中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (18): 1436-1439.

• 原著:脑损伤修复保护与再生 • 上一篇    

Botulinum toxin injection improved voluntary motor control in selected patients with post-stroke spasticity

  

  • 收稿日期:2012-01-04 修回日期:2012-03-26 出版日期:2012-06-25 发布日期:2012-06-25

Botulinum toxin injection improved voluntary motor control in selected patients with post-stroke spasticity

Shuo-Hsiu Chang1, 2, Gerard E Francisco1, 2, Sheng Li1, 2   

  1. 1  UT Health Motor Recovery Laboratory at the Institute for Rehabilitation and Research (TIRR), Memorial Hermann Hospital, Houston 77030, Texas, USA
    2  Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston 77030, Texas, USA
  • Received:2012-01-04 Revised:2012-03-26 Online:2012-06-25 Published:2012-06-25
  • Contact: Sheng Li, M.D., Ph.D., UT Health Motor Recovery Laboratory at the Institute for Rehabilitation and Research (TIRR), Memorial Hermann Hospital, Houston 77030, Texas, USA; Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston 77030, Texas, USA sheng.li@uth.tmc.edu
  • About author:Shuo-Hsiu Chang☆, Ph.D., P.T., Post-doctoral Research Associate, UT Health Motor Recovery Laboratory at the Institute for Rehabilitation and Research (TIRR), Memorial Hermann Hospital, Houston 77030, Texas, USA; Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston 77030, Texas, USA

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Abstract:

The effect of botulinum toxin type A injection on voluntary grip control was examined in a 53-year-old female, who sustained a hemorrhagic right middle cerebral artery stroke 3 years previously, which resulted in finger flexor spasticity and residual weak finger/wrist extension. The patient received 50 units of botulinum toxin type A injection each to the motor points (2 sites/muscle) of the left flexor digitorum superficialis and flexor digitorum profundus, respectively. Botulinum toxin injection led to weakness and tone reduction in the spastic finger flexors, but improved grip release time in grip initiation/release reaction time tasks. Improved release time was accompanied by shortened extensor electromyography activity, and improved release time likely correlated with blocked co-contraction of finger flexors during voluntary finger extension. This case report demonstrated that botulinum toxin injection improved voluntary motor control of the hand in a chronic stroke patient with residual finger extension.

Key words: botulinum toxin type A, spasticity, grip, stroke, neural regeneration