中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (17): 1318-1324.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy

  

  • 收稿日期:2012-01-06 修回日期:2012-04-12 出版日期:2012-06-15 发布日期:2012-06-15

Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy

Shaonian Xu, Jiachuan Liu, Yongming Zhang, Chunlin Wang, Jinbiao Wang, Yanyan Yang,   Jian Huo, Wenjiang Sun   

  1. Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China
  • Received:2012-01-06 Revised:2012-04-12 Online:2012-06-15 Published:2012-06-15
  • Contact: Jiachuan Liu, Master, Chief physician, Master’s supervisor, Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China ljc571017@sina.com
  • About author:Shaonian Xu★, Master, Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230031, Anhui Province, China

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Abstract:

We treated detonator-explosion-induced craniocerebral injury in rabbits with hyperbaric oxygen 1-24 hours post-injury. Expression of the apoptosis-regulating protein cytochrome c, the pro-apoptotic protein Bax and the apoptosis marker caspase-3 in the tissues surrounding the area of injury was significantly reduced, while that of the anti-apoptotic protein Bcl-2 was significantly increased. Our findings indicate that the curative effects of early hyperbaric oxygen on cortical cell apoptosis is associated with suppression of cytochrome c release from mitochondria. This mechanism underlies the observed reduction in Bax expression and upregulation of Bcl-2 expression.

Key words: hyperbaric oxygen, craniocerebral injury, caspase-3, cytochrome c, Bax, Bcl-2, neural regeneration