中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (17): 1325-1330.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in early focal cerebral infarction following urokinase  thrombolysis in rats

  

  • 收稿日期:2012-02-06 修回日期:2012-05-15 出版日期:2012-06-15 发布日期:2012-06-15

Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in early focal cerebral infarction following urokinase  thrombolysis in rats

Yuqiang Song1, Hongli Zou2, Guofeng Wang3, Hongxia Yang4, Zhaohong Xie4, Jianzhong Bi4   

  1. 1  Department of Neurology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China
    2  Qingdao Central Hospital, Qingdao 266042, Shandong Province, China
    3  Qingdao No. 9 People’s Hospital, Qingdao 266003, Shandong Province, China
    4  The Second Hospital of Shandong University, Jinan 255000, Shandong Province, China
  • Received:2012-02-06 Revised:2012-05-15 Online:2012-06-15 Published:2012-06-15
  • Contact: Hongli Zou, Master, Associate chief physician, Qingdao Central Hospital, Qingdao 266042, Shandong Province, China zouhl2009@sina.com
  • About author:Yuqiang Song☆, M.D., Associate chief physician, Department of Neurology, the Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China

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Abstract:

Activity of matrix metalloproteinase-9 increases following cerebral ischemia/reperfusion, and is associated with cerebral microvascular permeability, blood-brain barrier destruction, inflammatory cell infiltration and brain edema. Matrix metalloproteinase-9 also likely participates in thrombolysis. A rat model of middle cerebral artery infarction was established by injecting autologous blood clots into the internal carotid artery. At 3 hours following model induction, urokinase was injected into the caudal vein. Decreased neurological severity score, reduced infarct volume, and increased expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 were observed in the cerebral cortex 24 hours after urokinase thrombolysis. These results suggest that urokinase can suppress damage in the acute-early stage of cerebral infarction.

Key words: cerebral infarction, urokinase, thrombolysis, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, neural regeneration