中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (13): 1006-1012.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Paroxetine engenders analgesic effects through inhibition of p38 phosphorylation in a rat migraine model

  

  • 收稿日期:2011-11-01 修回日期:2012-02-24 出版日期:2012-05-05 发布日期:2012-05-05

Paroxetine engenders analgesic effects through inhibition of p38 phosphorylation in a rat migraine model

Chuanming Wang1, Wei Bi2, Yanran Liang1, Xiuna Jing1, Songhua Xiao1, Yannan Fang3,Qiaoyun Shi4, Enxiang Tao1   

  1. 1  Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
    2  Department of Neurology, First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China
    3  Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
    4  Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94304, USA
  • Received:2011-11-01 Revised:2012-02-24 Online:2012-05-05 Published:2012-05-05
  • Contact: Enxiang Tao, Ph.D., Chief physician, Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University,Guangzhou 510120,Guangdong Province, China taoenxiang@yahoo.com.cn
  • About author:Chuanming Wang☆, Ph.D.,Attending physician,Department of Neurology,Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China

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Abstract:

In this study, a model of migraine was established by electrical stimulation of the superior sagittal sinus in rats. These rats were then treated orally with paroxetine at doses of 2.5, 5, or 10 mg/kg per day for 14 days. Following treatment, mechanical withdrawal thresholds were significantly higher,extracellular concentrations of 5-hydroxytryptamine in the periaqueductal grey matter and nucleus reticularis gigantocellularis were higher, and the expression of phosphorylated p38 in the trigeminal nucleus caudalis was lower. Our experimental findings suggest that paroxetine has analgesic effects in a rat migraine model, which are mediated by inhibition of p38 phosphorylation.

Key words: paroxetine, migraine, 5-hydroxytryptamine, p38, phosphorylation, neural regeneration