中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (12): 885-890.

• 原著:退行性病与再生 •    下一篇

Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence- accelerated mouse

  

  • 收稿日期:2011-11-01 修回日期:2012-02-24 出版日期:2012-04-25 发布日期:2012-04-25

Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence- accelerated mouse

Zhanwei Zhang1, Ting Zhang2, Keli Dong2   

  1. 1 Department of Neurosurgery, First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China
    2 Department of Traditional Chinese Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
  • Received:2011-11-01 Revised:2012-02-24 Online:2012-04-25 Published:2012-04-25
  • Contact: Ting Zhang, Attending physician, Studying for doctorate, Department of Traditional Chinese Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China zhangting8107@126.com
  • About author:Zhanwei Zhang★, Master, Attending physician, Department of Neurosurgery, First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China

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Abstract:

At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein. These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.

Key words: icariin, Alzheimer’s disease, hippocampus, phosphorylated cyclic adenosine monophosphate response element binding protein, neural regeneration