中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (12): 891-895.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid

  

  • 收稿日期:2011-11-24 修回日期:2012-03-05 出版日期:2012-04-25 发布日期:2012-04-25

Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid

Guifang Sun1, Zhihao Yuan2, Boai Zhang1, Yanjie Jia1, Yangfei Ji1, Xingrong Ma1, Yu Liu1, Yanru Liu1, Quanqing Wen3, Yanling Zhao1   

  1. 1 Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China
    2 Department of Urology, the Third People’s Hospital of Zhengzhou, Zhengzhou 450051, Henan Province, China
    3 Department of Neurology, the Central Hospital of Nanyang, Nanyang 473009, Henan Province, China
  • Received:2011-11-24 Revised:2012-03-05 Online:2012-04-25 Published:2012-04-25
  • Contact: Boai Zhang, Professor, Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China zhangboaidoctor@hotmail. com.cn
  • About author:Guifang Sun★, Master, Attending physician, Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China

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Abstract:

Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100-4 000 μM kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone. Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons.

Key words: kainic acid, gastrodin, neural stem cells, differentiation