中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (4): 628-634.doi: 10.4103/1673-5374.295270

• 综述:退行性病与再生 • 上一篇    下一篇

益生菌在神经退行性疾病中的新兴作用:帕金森病的新希望?

  

  • 出版日期:2021-04-15 发布日期:2020-12-21

The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson’s disease?

Vanessa Castelli1, #, Michele d’Angelo1, *, #, Massimiliano Quintiliani1, 2, Elisabetta Benedetti1, Maria Grazia Cifone1, Annamaria Cimini1, 3, *#br#   

  1. 1 Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy;  2 SIRE Srl, Naples, Italy;  3 Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Philadelphia, PA, USA
  • Online:2021-04-15 Published:2020-12-21
  • Contact: Annamaria Cimini, annamaria.cimini@univaq.it; Michele d’Angelo, PhD, michele.dangelo@univaq.it.

摘要:

https://orcid.org/0000-0002-2737-7970 (Annamaria Cimini); 

https://orcid.org/0000-0002-3693-840X (Michele d’Angelo) 

Abstract: Neurodegenerative disease etiology is still unclear, but different contributing factors, such as lifestyle and genetic factors are involved. Altered components of the gut could play a key role in the gut-brain axis, which is a bidirectional system between the central nervous system and the enteric nervous system. Variations in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic, autoimmune, cancer, and, notably, neurodegenerative disorders. Diet can alter the microbiota composition, affecting the gut-brain axis function. Different nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions, including the use of probiotics. Preclinical and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry, modulating different pathways. This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy, confirming that gut microbiota modulation influences different pro-survival pathways. Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary.

Key words: age-related diseases, brain, dysbiosis, gut-brain axis, microbiota, neurodegeneration, nutraceuticals, Parkinson’s disease, probiotics, SLAB51