中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (9): 675-679.

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

Immune reactions and nerve repair in mice with sciatic nerve injury 14 days after intraperitoneal injection of Brazil

  

  • 收稿日期:2011-10-26 修回日期:2012-02-02 出版日期:2012-03-25 发布日期:2012-03-25

Immune reactions and nerve repair in mice with sciatic nerve injury 14 days after intraperitoneal injection of Brazil

Jian Cao1, Zhongping Niu1, Yongan Wang1, Yiwen Jiang1, Haoyu Liu2, Binfeng Wang1, Weitian Yin2, Lisen Li2   

  1. 1 Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China
    2 Department of Hand Surgery, China-Japanese Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
  • Received:2011-10-26 Revised:2012-02-02 Online:2012-03-25 Published:2012-03-25
  • Contact: Lisen Li, M.D., Associate professor, Department of Hand Surgery, China-Japanese Union Hospital of Jilin University, Changchun 130033, Jilin Province, China; Jian Cao, Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China lisenli@sina.com;Caojian2005088@yahoo.cn
  • About author:Lisen Li, M.D., Associate professor, Department of Hand Surgery, China-Japanese Union Hospital of Jilin University, Changchun 130033, Jilin Province, China; Jian Cao, Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China lisenli@sina.com;Caojian2005088@yahoo.cn

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Abstract:

BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune complex concentration were significantly reduced, and the morphology of the soleus muscle was restored in mice with sciatic nerve injury. These effects of Brazil were dose-dependent. Our experimental findings indicate that Brazil can regulate immune responses after nerve injury and promote sciatic nerve repair.

Key words: Brazil, peripheral nerve injury, repair, neural regeneration, immune