中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (8): 578-582.

• 原著:颅神经损伤修复保护与再生 • 上一篇    下一篇

Recombinant human erythropoietin increases cerebral cortical width index and neurogenesis following ischemic stroke

  

  • 收稿日期:2011-10-16 修回日期:2012-01-18 出版日期:2012-03-15 发布日期:2012-03-15

Recombinant human erythropoietin increases cerebral cortical width index and neurogenesis following ischemic stroke

Zhongmin Wen1, Peiji Wang2   

  1. 1 Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
    2 Department of Orthopedics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
  • Received:2011-10-16 Revised:2012-01-18 Online:2012-03-15 Published:2012-03-15
  • Contact: Peiji Wang, Master, Associate professor, Chief physician, Department of Orthopedics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China wangpeiji88@163.com
  • About author:Zhongmin Wen☆, M.D., Associate chief physician, Lecturer, Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China

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Abstract:

The cerebral cortical expansion index refers to the ratio between left and right cortex width and is recognized as an indicator for cortical hyperplasia. Cerebral ischemia was established in CB-17 mice in the present study, and the mice were subsequently treated with recombinant human erythropoietin via subcutaneous injection. Results demonstrated that cerebral cortical width index significantly increased. Immunofluorescence detection showed that the number of nuclear antigen antibody/5-bromodeoxyuridine-positive cells at the infarction edge significantly increased. Correlation analysis revealed a negative correlation between neurological scores and cortical width indices in rats following ischemic stroke. These experimental findings suggested that recombinant human erythropoietin promoted cerebral cortical hyperplasia, increased cortical neurogenesis, and enhanced functional recovery following ischemic stroke.

Key words: cerebral infarction, erythropoietin, neural regeneration, neurogenesis