中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (8): 583-587.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Protective effects of remote ischemic preconditioning in rat hindlimb on ischemia- reperfusion injury

  

  • 收稿日期:2011-11-03 修回日期:2012-02-16 出版日期:2012-03-15 发布日期:2012-03-15

Protective effects of remote ischemic preconditioning in rat hindlimb on ischemia- reperfusion injury

Ying Zhang1, 2, Xiangrong Liu1, 3, Feng Yan1, 3, Lianqiu Min4, Xunming Ji1, 3, Yumin Luo1, 3   

  1. 1  Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, Beijing 100053, China
    2  Department of Neurology, Xuanwu Hospital of Capital Medical University, Capital Medical University, Ministry of Education, Beijing 100053, China
    3  Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Ministry of Education, Beijing 100053, China
    4  Department of Neurology, Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China
  • Received:2011-11-03 Revised:2012-02-16 Online:2012-03-15 Published:2012-03-15
  • Contact: Yumin Luo, M.D., Professor, Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, Beijing 100053, China; Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Ministry of Education, Beijing 100053, China yumin111@ccmu.edu.cn
  • About author:Ying Zhang★, Studying for master?s degree, Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, Beijing 100053, China; Department of Neurology, Xuanwu Hospital of Capital Medical University, Capital Medical University, Ministry of Education, Beijing 100053, China

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Abstract:

Three cycles of remote ischemic pre-conditioning induced by temporarily occluding the bilateral femoral arteries (10 minutes) prior to 10 minutes of reperfusion were given once a day for 3 days before the animal received middle artery occlusion and reperfusion surgery. The results showed that brain infarct volume was significantly reduced after remote ischemic pre-conditioning. Scores in the forelimb placing test and the postural reflex test were significantly lower in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. Thus, neurological function was better in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. These results indicate that remote ischemic pre-conditioning in rat hindlimb exerts protective effects in ischemia-reperfusion injury.

Key words: cerebral ischemia-reperfusion, remote ischemic preconditioning, stroke, neural regeneration