中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (9): 1805-1806.doi: 10.4103/1673-5374.306085

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

人工耳蜗植入术后无缝隙神经电极界面的研究进展

  

  • 出版日期:2021-09-15 发布日期:2021-02-05

Recent advancements toward gapless neural-electrode interface post-cochlear implantation

Crystal Y. Li, Rahul Mittal, Jenna Bergman, Jeenu Mittal, Adrien A. Eshraghi*   

  1. Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA 
    (Li CY, Mittal R, Bergman J, Mittal J, Eshraghi AA)
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA (Eshraghi AA)
    Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA (Eshraghi AA)
  • Online:2021-09-15 Published:2021-02-05
  • Contact: Adrien A. Eshraghi, MD, MSc, FACS, aeshraghi@med.miami.edu.
  • Supported by:
    The cochlear implant research work in Dr Eshraghi’s laboratory is supported by translational grants from MED-EL Corporation and HERA Foundation.

摘要: https://orcid.org/0000-0002-1559-8573
(Adrien A. Eshraghi) 

Abstract: Cochlear implants (CI) are widely used to provide auditory rehabilitation to individuals with moderate to severe sensorineural hearing loss (Eshraghi et al., 2012). The scala tympani (ST) of the cochlea is the site of implantation of the intracochlear electrode array. In a healthy, normal ear, the cell bodies of the spiral ganglion neurons (SGNs) reside in Rosenthal’s canal, a small cavity adjacent to the ST. SGNs have a peripheral neurite that projects to the hair cells on the basilar membrane of the organ of corti, and a central axon that projects to the brainstem via the auditory nerve (Landry et al., 2013). From SGN cell bodies, the dendrites extend through the modiolus and the osseous spiral lamina to make synaptic contact with hair cells in the organ of corti (Rusznák et al., 2009). In severe to profound deafness, the cochlea has few to no hair cells (Shibata et al., 2010). A CI helps overcome the problem of functional hair cells by directly stimulating the SGNs in the inner ear via short biphasic electric pulses (Li et al., 2017).