中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (1): 57-63.doi: 10.4103/1673-5374.343897

• 综述:退行性病与再生 • 上一篇    下一篇

氧疗对阿尔茨海默病的神经保护

  

  • 出版日期:2023-01-15 发布日期:2022-06-16

The neuroprotective effects of oxygen therapy in Alzheimer’s disease: a narrative review

Cui Yang1, 2, 3, #, Qiu Yang1, 2, 3, #, Yang Xiang2, 3, Xian-Rong Zeng3, 4, Jun Xiao5, Wei-Dong Le2, 3, *   

  1. 1School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China; 2Institute of Neurology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China; 3Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan Province, China; 4Department of Hyperbaric Oxygen, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China; 5Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan Province, China
  • Online:2023-01-15 Published:2022-06-16
  • Contact: Wei-Dong Le, MD, PhD, wdle@sibs.ac.cn.
  • Supported by:
    This work was supported by the Key Research and Development Support Project of Chengdu Science and Technology Bureau, No. 2019-YF05-00655-SN (to WDL) and the Key Project of the Medical Science Department, University of Electronic Science and Technology of China, No. ZYGX2020ZB035 (to WDL).

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摘要： https://orcid.org/0000-0001-7459-2705 (Wei-Dong Le)

Abstract: Alzheimer’s disease (AD) is a degenerative neurological disease that primarily affects the elderly. Drug therapy is the main strategy for AD treatment, but current treatments suffer from poor efficacy and a number of side effects. Non-drug therapy is attracting more attention and may be a better strategy for treatment of AD. Hypoxia is one of the important factors that contribute to the pathogenesis of AD. Multiple cellular processes synergistically promote hypoxia, including aging, hypertension, diabetes, hypoxia/obstructive sleep apnea, obesity, and traumatic brain injury. Increasing evidence has shown that hypoxia may affect multiple pathological aspects of AD, such as amyloid-beta metabolism, tau phosphorylation, autophagy, neuroinflammation, oxidative stress, endoplasmic reticulum stress, and mitochondrial and synaptic dysfunction. Treatments targeting hypoxia may delay or mitigate the progression of AD. Numerous studies have shown that oxygen therapy could improve the risk factors and clinical symptoms of AD. Increasing evidence also suggests that oxygen therapy may improve many pathological aspects of AD including amyloid-beta metabolism, tau phosphorylation, neuroinflammation, neuronal apoptosis, oxidative stress, neurotrophic factors, mitochondrial function, cerebral blood volume, and protein synthesis. In this review, we summarized the effects of oxygen therapy on AD pathogenesis and the mechanisms underlying these alterations. We expect that this review can benefit future clinical applications and therapy strategies on oxygen therapy for AD.

Key words: Alzheimer’s disease, amyloid-beta metabolism, clinical symptoms, hypoxia, neuroinflammation, neuronal apoptosis, oxygen therapy, pathogenesis, risk factor, tau phosphorylation