中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (1): 64-67.doi: 10.4103/1673-5374.345472

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

安全漏洞:周围神经为毒素输送到中枢神经系统提供了不受限制的通道

  

  • 出版日期:2023-01-15 发布日期:2022-06-16

Security breach: peripheral nerves provide unrestricted access for toxin delivery into the central nervous system

Igor Lupinski, Allison S. Liang, Randall D. McKinnon*   

  1. Department of Neurosurgery and Member, The Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ, USA
  • Online:2023-01-15 Published:2022-06-16
  • Contact: Randall D. McKinnon, PhD, mckinnon@rwjms.rutgers.edu.
  • Supported by:
    This work was supported by grants from the New Jersey Commission on Spinal Cord Research (05-3047; 11-015). 

摘要: https://orcid.org/0000-0002-7539-9613 (Randall D. McKinnon)

Abstract: We explore the hypothesis that a potential explanation for the initiation of motor neuron disease is an unappreciated vulnerability in central nervous system defense, the direct delivery of neurotoxins into motor neurons via peripheral nerve retrograde transport.  This further suggests a mechanism for focal initiation of neuro-degenerative diseases in general, with subsequent spread by network degeneration as suggested by the Frost-Diamond hypothesis.  We propose this vulnerability may be a byproduct of vertebrate evolution in a benign aquatic environment, where external surfaces were not exposed to concentrated neurotoxins.

Key words: amyotrophic lateral sclerosis, bioaccumulation, neurodegeneration, neuropathology, neurotoxins, peripheral nerves, retrograde transport, retrotoxicity, suicide transport