中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (2): 339-340.doi: 10.4103/1673-5374.346483

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

PANoptosis 在神经元细胞死亡中的潜在作用:评论“视网膜神经元缺血/再灌注损伤中的 PANoptosis 样细胞死亡”

  

  • 出版日期:2023-02-15 发布日期:2022-08-06

Potential role of PANoptosis in neuronal cell death: commentary on “PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons”

Yanyan Sun, Changlian Zhu*   

  1. Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China (Sun Y, Zhu C)
    Department of Human Anatomy, School of Basic Medicine, Zhengzhou University, Zhengzhou, Henan Province, China (Sun Y)
    Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China; Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Göteborg, Sweden (Zhu C) 
  • Online:2023-02-15 Published:2022-08-06
  • Contact: Changlian Zhu, MD, PhD, changlian.zhu@neuro.gu.se
  • Supported by:
    Related work was supported by the National Nature Science Foundation of China (81901335 to YS, U21A20347 to CZ), China Postdoctoral Science Foundation (2020M672288 to YS) and Henan Postdoctoral Research Grant (201902007 to YS).

摘要: https://orcid.org/0000-0002-5029-6730 (Changlian Zhu)

Abstract: Extensive neuronal cell death occurs during nervous system development to remove surplus, unwanted, and damaged cells. This is a highly regulated physiological process that plays a pivotal role in nervous system homeostasis and normal development. In some brain regions, more than half of the neurons are removed during normal development without interfering with the remaining cells. This gene-regulated neuronal cell deletion process is called programmed cell death (Fricker et al., 2018). However, under pathological conditions such as brain ischemia or hemorrhage and neurodegenerative and neuroinflammatory disorders, neuronal cell death may occur through gene-regulated cell death or accidental cell death in specific brain regions depending on the severity of the pathological stimuli. Accidental cell death is an uncontrolled or unavoidable biological process that involves immediate breakdown of cellular structures resulting from severe physiochemical or mechanical insult. Regulated cell death is closely integrated with signaling cascades and molecular processes that can be altered by pharmacological or genetic interventions (Cui et al., 2021).