中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (2): 341-.doi: 10.4103/1673-5374.346543

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

关于“视网膜神经元缺血/再灌注损伤中的 PANoptosis 样细胞死亡”的评论

  

  • 出版日期:2023-02-15 发布日期:2022-08-06

Commentary on “PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons”

Macarena S. Arrázola, Felipe A. Court*   

  1. Center for Integrative Biology, Faculty of Sciences, Universidad Mayor; Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile (Arrázola MS, Court FA)
    Buck Institute for Research on Aging, Novato, CA, USA (Court FA)
  • Online:2023-02-15 Published:2022-08-06
  • Contact: Felipe A. Court, PhD, felipe.court@umayor.cl.
  • Supported by:
    This work was supported by grants from the Geroscience Center for Brain Health and Metabolism, FONDAP- 15150012 (to FAC), Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) No. 1150766 (to FAC), Agencia Nacional de Investigación y Desarrollo (ANID) FONDECYT Iniciación N° 11220120 (to MSA).

摘要: https://orcid.org/0000-0002-9394-7601 (Felipe A. Court)

Abstract: Several decades have passed since programmed-cell death (PCD) was identified. Apoptosis was first defined by Kerr in 1972, and later described by the Nobel Prices in Physiology or Medicine 2002, Sydney Brenner, John Sulston and Robert Horwitz, who defined genetic regulators of apoptosis (Diamantis et al., 2008). However, it was in 1858 when the German pathologist and biologist Rudolf Virchow identified for the first time the phenomenon of apoptosis, which he named necrobiosis, arguing that this form of cell death was completely different from the uncontrolled necrosis, suggesting the existence of two different types of cell death. Today, the knowledge in the field of cell death regulation is extensive, but still under continuous expansion.