中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (3): 197-201.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus

  

  • 收稿日期:2011-09-19 修回日期:2011-11-15 出版日期:2012-01-25 发布日期:2012-01-25

Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus

Zhihong Chen1, Yaqiang He1, Chengjun Song1, Zhijun Dong2, Zhejun Su2, Jingfeng Xue1   

  1. 1 Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China
    2 Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China
  • Received:2011-09-19 Revised:2011-11-15 Online:2012-01-25 Published:2012-01-25
  • Contact: Jing-feng Xue, Master, Professor, Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China xjf@cdmc.edu.cn
  • About author:Zhihong Chen☆, Doctor, Professor, Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China

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Abstract:

In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.

Key words: sericin, type 2 diabetes mellitus, hippocampus, apoptosis, Akt signal transduction pathway, neural regeneration