中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (3): 202-206.

• 原著:视神经损伤修复保护与再生 • 上一篇    下一篇

Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus

  

  • 收稿日期:2011-10-28 修回日期:2011-12-10 出版日期:2012-01-25 发布日期:2012-01-25

Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus

Zhijun Dong, Xiangyi Tao, Xiaoxiao Fu, Haibin Wang, Donghua Wang, Tiemin Zhang   

  1. Department of Ophthalmology, Chengde Medical College Affiliated Hospital, Chengde 067000, Hebei Province, China
  • Received:2011-10-28 Revised:2011-12-10 Online:2012-01-25 Published:2012-01-25
  • Contact: Tie-min Zhang, Master, Profes-sor, Department of Ophthal-mology, Chengde Medical College Affiliated Hospital, Chengde 067000, Hebei Province, China zhangtiemin1956@126.com
  • About author:Zhijun Dong★, Master, Attending physician, De-partment of Ophthalmology, Chengde Medical College Affiliated Hospital, Chengde 067000, Hebei Province, China

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Abstract:

This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuous intraperitoneal injection of streptozotocin. The results showed that Purendan superfine powder could upregulate the expression of bcl-2 protein and mRNA, and downregulate the expression of bax and caspase-3 in the retina of diabetes mellitus rats. In addition, Purendan superfine powder was shown to reduce the number of apoptotic neurons. Our experimental findings indicate that Purendan superfine powder can inhibit neuronal apoptosis in the retina of diabetes mellitus rats and has protective effects on diabetic retinopathy.

Key words: Purendan superfine powder, diabetic retinopathy, bcl-2, bax, caspase-3, cellular apoptosis