中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (1): 13-17.

• 原著:视神经损伤修复保护与再生 • 上一篇    下一篇

Experience-dependent expression of Nogo-A and Nogo receptor in the developing rat visual cortex

  

  • 收稿日期:2011-05-25 修回日期:2011-07-12 出版日期:2012-01-05 发布日期:2012-01-05

Experience-dependent expression of Nogo-A and Nogo receptor in the developing rat visual cortex

Xiaoying Wu, Yulin Luo, Shuangzhen Liu, Kuanshu Li   

  1. Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
  • Received:2011-05-25 Revised:2011-07-12 Online:2012-01-05 Published:2012-01-05
  • Contact: Xiaoying Wu, Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China wux-iaoyingxy@yahoo.cn
  • About author:Xiaoying Wu, Professor, Department of Ophthalmolo-gy, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China

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Abstract:

Nogo-A and Nogo receptor (NgR) expression in the visual cortex following a critical developmental period (postnatal days 20-60) has been previously shown. However, little is known regarding Nogo-A and NgR expression between postnatal day 0 and initiation of the critical period. The present study analyzed Nogo-A and NgR expression at four different time points: postnatal day 0 (P0), before critical period (P14), during critical period (P28), and after critical period (P60). Results showed significantly increased Nogo-A mRNA and protein expression levels in the visual cortex following birth, and expression levels remained steady between P28 and P60. NgR mRNA or protein expression was dramatically upregulated with age and peaked at P14 or P28, respectively, and maintained high expression to P60. In addition, Nogo-A and NgR expression was analyzed in each visual cortex layer in normal developing rats and rats with monocular deprivation. Monocular deprivation decreased Nogo-A and NgR mRNA and protein expression in the rat visual cortex, in particular in layers II-III and IV in the visual cortex contralateral to the deprived eye. These findings suggested that Nogo-A and NgR regulated termination of the critical period in experience- dependent visual cortical plasticity.

Key words: monocular deprivation, neural regeneration, Nogo receptor, Nogo-A, plasticity, primary visual cortex