中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (35): 2818-2825.

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

干细胞移植修复脊髓损伤的文献质量

  

  • 收稿日期:2012-09-15 修回日期:2012-10-10 出版日期:2012-12-15 发布日期:2012-12-15

Transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cordinjury

Xing Zhang1, Fei Yin1, Li Guo2, Dongxu Zhao1, Gu Gong1, Lei Gao3, Qingsan Zhu1   

  1. 1 Department of Spine Surgery, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China
    2 Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China
    3 Department of Pathogenobiology, Norman Bethune College of Medicine, Jilin University; Jilin University Mycology Research Center (JUMRC), Changchun 130021, Jilin Province, China
  • Received:2012-09-15 Revised:2012-10-10 Online:2012-12-15 Published:2012-12-15
  • Contact: Qingsan Zhu, Professor,Doctoral supervisor,Department of Spine Surgery,the First Hospital of Jilin University, Changchun,130021, Jilin Province, China drzqs@yahoo.com.cn
  • About author:Xing Zhang☆, Studying for doctorate, Department of Spine Surgery, the First Hospital of Jilin University,Changchun, 130021, Jilin Province, China

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Abstract:

OBJECTIVE: To identify global research trends in transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury.DATA RETRIEVAL: We performed a bibliometric analysis of studies on transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury published from 2002 to 2011 and retrieved from the Web of Science, using the key words spinal cord injury along with either neural stem cell, Schwann cell or olfactory ensheathing cell.SELECTION CRITERIA: Inclusion criteria: (a) peer-reviewed published articles on neural stem cells,Schwann cells or olfactory ensheathing cells for spinal cord injury indexed in the Web of Science; (b)original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial materials and news items; and (c) published between 2002 and 2011. Exclusion criteria: (a) articles that required manual searching or telephone access; (b) documents that were not published in the public domain; and (c) corrected papers.MAIN OUTCOME MEASURES: (1) Annual publication output, distribution by journal, distribution by institution and top-cited articles on neural stem cells; (2) annual publication output, distribution by journal, distribution by institution and top-cited articles on Schwann cells; (3) annual publication output, distribution by journal, distribution by institution and top-cited articles on olfactory ensheathing cells.RESULTS: This analysis, based on articles indexed in the Web of Science, identified several research trends among studies published over the past 10 years in transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury. The number of publications increased over the 10-year period examined. Most papers appeared in journals with a focus on neurology, such as Journal of Neurotrauma, Experimental Neurology and Glia. Research institutes publishing on the use of neural stem cells to repair spinal cord injury were mostly in the USA and Canada. Those publishing on the use of Schwann cells were mostly in the USA and Canada as well. Those publishing on the use of olfactory ensheathing cells were mostly in the UK,the USA and Canada.CONCLUSION: On the basis of the large number of studies around the world, cell transplantation has proven to be the most promising therapeutic approach for spinal cord injury.

Key words: spinal cord, neuron, nerve fiber, neural stem cell, Schwann cell, olfactory ensheathing cell;
transplantation, genetic engineering, tissue engineering, neural regeneration