中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (26): 2458-2467.doi: 10.3969/j.issn.1673-5374.2013.26.007
甲状腺功能减退改变2型糖尿病海马胶质细胞形态
Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes
Sung Min Nam1, Yo Na Kim1, Dae Young Yoo1, Sun Shin Yi2, Jung Hoon Choi3, In Koo Hwang1, Je Kyung Seong1, Yeo Sung Yoon1
- 1 Department of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, South Korea
2 Department of Biomedical Laboratory Science, College of Biomedical Sciences, Soonchunhyang University, Asan 336-745, South Korea
3 Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 200-701, South Korea
摘要：
为观察甲状腺功能减退对2型糖尿病大鼠海马胶质细胞形态的影响，在Zucker糖尿病肥胖大鼠和Zucker对照大鼠7周龄时，喂饲溶剂或抗甲状腺药甲巯咪唑治疗5周。治疗结束时，甲巯咪唑治疗的大鼠血清游离三碘甲腺原氨酸(T3)和甲状腺素水平明显下降，且这种变化在Zucker糖尿病肥胖大鼠中尤其明显。胶质纤维酸性蛋白免疫阳性的星形胶质细胞和离子钙接头分子1免疫阳性的小胶质细胞在Zucker糖尿病肥胖大鼠和Zucker对照大鼠海马CA1区和齿状回有广泛分布，且在两种大鼠间无明显差异。然而，经甲巯咪唑治疗后，两种大鼠海马CA1区和齿状回星形胶质细胞和小胶质细胞免疫阳性表达明显减弱。实验表明，糖尿病对星形胶质细胞和小胶质细胞形态无明显影响，但若并发甲状腺功能减退，则两种胶质细胞反应减弱。