中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (36): 2901-2906.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

 电针减轻脑缺血再灌注后血脑屏障损伤：谁在起作用

  

  • 收稿日期:2012-07-02 修回日期:2012-10-29 出版日期:2012-12-25 发布日期:2012-12-25

Electroacupuncture reduces injury to the blood-brain barrier following cerebral ischemia/ reperfusion injury

Yongjun Peng, Hesheng Wang, Jianhua Sun, Li Chen, Meijuan Xu, Jihong Chu   

  1. Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
  • Received:2012-07-02 Revised:2012-10-29 Online:2012-12-25 Published:2012-12-25
  • Contact: Yongjun Peng, Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province,China pengyongjun2004@126.com
  • About author:Yongjun Peng☆, M.D.,Associate chief physician,Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province,China

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Abstract:

This study used electroacupuncture at Renzhong (DU26) and Baihui (DU20) in a rat model of cerebral ischemia/reperfusion injury. Neurological deficit scores, western blotting, and reverse transcription-PCR results demonstrated that electroacupuncture markedly reduced neurological deficits, decreased corpus striatumaquaporin-4 protein and mRNA expression, and relieved damage to the blood-brain barrier in a rat model of cerebral ischemia/reperfusion injury. These results suggest that electroacupuncture most likely protects the blood brain barrier by regulating aquaporin-4 expression following cerebral ischemia/reperfusion injury.

Key words: electroacupuncture, cerebral ischemia/reperfusion, blood-brain barrier, aquaporin-4, brain edema;rat, Renzhong (DU26), Baihui (DU20), brain injury, regeneration, neural regeneration