1.N-acetyl aspartate, choline and creatine levels in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls.
2.There were no significant differences in N-acetyl aspartate/choline or choline/creatine ratios in the medial prefrontal cortex between patients with bipolar disorder and healthy controls. Illness duration was positively correlated with choline level in the right medial prefrontal cortex.
3.During the euthymic period, abnormalities in cellular energy metabolism and membrane phospholipid metabolism were present, and this could compromise neuronal activity and integrity in the medial prefrontal cortex.
1.双相性精神障碍患者双侧内侧额叶前皮质乙酰基天门冬氨酸、胆碱、肌酸水平明显低于健康对照。
2.双相性精神障碍患者双侧内侧额叶前皮质乙酰基天门冬氨酸/肌酸和胆碱/肌酸比值与健康对照无明显差异,病程与右侧内侧额叶前皮质胆碱水平呈明显正相关。
3.胸腺功能正常的双相性精神障碍患者内侧额叶前皮质细胞活性和整合能力下降,细胞能量代谢和膜磷脂代谢异常。