中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (36): 2937-2943.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

正电子发射型计算机断层显像/CT定位癫痫病灶伽玛刀治疗难治性癫痫

  

  • 收稿日期:2012-05-05 修回日期:2012-08-24 出版日期:2012-12-25 发布日期:2012-12-25

Gamma knife treatment for refractory epilepsy in seizure focus localized by positron emission tomography/CT

Xia Bai1, Xuemei Wang1, Hongwei Wang2, Shigang Zhao3, Xiaodong Han4, Linjun Hao5,Xiangcheng Wang1   

  1. 1 Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region,China
    2 Department of Gamma Knife Center, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China
    3 Department of Neurology, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China
    4 Department of MRI Center, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region,China
    5 Department of Emergency Medical Center, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China
  • Received:2012-05-05 Revised:2012-08-24 Online:2012-12-25 Published:2012-12-25
  • Contact: Xuemei Wang, M.D.,Professor, Chief physician,Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050,Inner Mongolia Autonomous Region, China wangxuemei2260@yahoo.com.cn
  • About author:Xia Bai★, Master,Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050,Inner Mongolia Autonomous Region, China

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Abstract:

A total of 80 patients with refractory epilepsy were recruited from the Inner Mongolia Medical College Affiliated Hospital. The foci of 60% of the patients could be positioned using a combined positron emission tomography/CT imaging modality. Hyper- and hypometabolism foci were examined as part of this study. Patients who had abnormal metabolism in positron emission tomography/CT imaging were divided into intermittent-phase group and the seizure-phase group.The intermittent-phase group was further divided into a single-focus group and a multiple-foci group according to the number of seizure foci detected by imaging. Following gamma knife treatment,seizure frequency was significantly lower in the intermittent-phase group and the seizure-phase group. Wieser’s classification reached Grade I or II in nearly 40% of patients. Seizure frequency was significantly lower following treatment, but Wieser’s classification score was significantly higher in the seizure-phase group compared with the intermittent-phase group. Seizure frequency was significantly lower following treatment in the single-focus group, but Wieser’s classification score was significantly higher in the single-focus group as compared with the multiple-foci group.

Key words: epilepsy, seizure, positron emission tomography/CT, gamma knife radiosurgery, metabolism;18F-fluorodeoxyglucose, neural regeneration