中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2012, Vol. 7 ›› Issue (33): 2600-2606.

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

热敏灸减轻局灶性脑缺血再灌注损伤的炎症反应

  

  • 收稿日期:2012-07-05 修回日期:2012-10-07 出版日期:2012-11-25 发布日期:2012-11-25

Heat-sensitive moxibustion attenuates the inflammation after focal cerebral ischemia/reperfusion injury

Aijiao Xiao1, Rixin Chen2, Mingfei Kang2, Shenghai Tan3   

  1. 1 Basal Medical College of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China
    2 Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, Jiangxi Province, China
    3 Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China
  • Received:2012-07-05 Revised:2012-10-07 Online:2012-11-25 Published:2012-11-25
  • Contact: Aijiao Xiao, Basal Medical College of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004,Jiangxi Province, China xaj527@163.com
  • About author:Aijiao Xiao☆, M.D.,Associate professor, Basal Medical College of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province,China

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Abstract:

Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui (DU14) for 35 minutes. Results showed that suspended moxibustion decreased infarct volume, reduced cortical myeloperoxidase activity, and suppressed serum levels of proinflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Our experimental findings indicated that heat-sensitive moxibustion can attenuate inflammation and promote repair after focal cerebral ischemia/reperfusion injury.

Key words: suspended moxibustion, heat-sensitive moxibustion, traditional suspended moxibustion, middle cerebral artery occlusion, cerebral ischemia/reperfusion injury, infarct volume, proinflammatory cytokines, interleukin, myeloperoxidase, traditional Chinese medicine, neural regeneration