1.Because there have been no previous controlled comparisons, in this study, to provide objective and convincing results, brain activation was compared under heroin cue exposure, heroin cue exposure plus acupuncture at the Zusanli point (ST36) without twirling of the needle, and heroin cue exposure plus acupuncture at the Zusanli point with twirling of the needle.
2.Heroin cues exposure activated craving-related brain regions such as the frontal lobe, which have been associated with reward, learning and memory, cognition, and emotion.
3.Because acupuncture at the Zusanli point with twirling of the needle rapidly suppressed the activation of the craving-related brain regions, it may be a viable intervention for drug craving.
1.国内外此类研究未设非依赖者比较。我们在观察研究过程中分别设立了海洛因线索诱发、海洛因线索诱发+针刺足三里穴(非捻针)状态、海洛因线索诱发+针刺足三里穴捻针状态的脑fMRI检测比较,结果客观,说服力强。
2.海洛因线索诱发可激活额叶等与渴求相关的奖赏、学习记忆、认知、情绪等特异脑区。
3.针刺足三里穴捻针对与心理渴求相关脑区的激活具有即刻抑制作用,具有干预心理渴求的潜力。