中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (2): 205-212.doi: 10.4103/1673-5374.125351

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

温胆汤改善失眠后焦虑的作用与脑肠肽有关

  

  • 收稿日期:2013-12-05 出版日期:2014-01-10 发布日期:2014-01-10

Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin

Liye Wang, Yuehan Song, Feng Li, Yan Liu, Jie Ma, Meng Mao, Fengzhi Wu, Ying Wu, Sinai Li, Binghe Guan, Xiaolan Liu   

  1. Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China
  • Received:2013-12-05 Online:2014-01-10 Published:2014-01-10
  • Contact: Feng Li, Ph.D., Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing 100029, China, lifeng95@vip.sina.com. Yuehan Song, Ph.D., Associate professor, Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing 100029, China, songyuehan1981@126.com.

摘要:

既往研究认为Ghrelin可诱导焦虑等异常情绪,因而推测Ghrelin这一脑肠肽参与失眠对情绪的影响。由于温胆汤可改善失眠引起的焦虑,其治疗范围与脑肠轴相对应,考虑其治疗机制可能与脑肠轴相关。实验以此为理论依据,建立睡眠剥夺大鼠模型,并在造模期间给予温胆汤灌胃治疗。结果证实温胆汤可明显改善睡眠剥夺所致大鼠的焦虑情绪,抑制睡眠剥夺所引起的Ghrelin表达下降,其中在下丘脑中改善作用更明显,但增加下丘脑中Ghrelin受体mRNA表达。因而认为温胆汤通过调节Ghrelin-Ghrelin受体,改善失眠所致的焦虑。

关键词: 神经再生, 中医药, 温胆汤, 睡眠剥夺, 焦虑, Ghrelin, Ghrelin受体, 基金资助文章