中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (3): 229-231.doi: 10.4103/1673-5374.128212

• 观点:脊髓损伤修复保护与再生 •    下一篇

运用神经干细胞桥接损伤脊髓:轴突可以远程生长吗?

  

  • 出版日期:2014-02-15 发布日期:2014-02-15

Bridging the injured spinal cord with neural stem cells

Jennifer N. Dulin1, Paul Lu1, 2   

  1. 1 Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; 2 Veterans Administration Medical Center, San Diego, CA, 92161, USA
  • Online:2014-02-15 Published:2014-02-15
  • Supported by:

    This work was funded by grants from the Veterans Administration, the Canadian Spinal Research Organization and the California Institute for Regenerative Medicine.

摘要:

脊髓损伤不仅破坏脑灰质神经元,而且伤害传输大脑信号的白质轴突束 ,导致永久性的损伤平面以下的功能丧失。神经干细胞具有形成中间神经元的潜能,可桥接分离后的脊髓节段的功能连通,因此,对重建受损脊髓有很高的治疗潜力。这过程需要宿主轴突再生并与受赠神经元连通,生长的轴突及受赠神经元连通在宿主内形成一个中枢神经环路。本文将讨论探索脊髓损伤模型中桥接的神经干细胞形成中间神经元的新思路,着重强调移植神经干细胞的远程轴突生长及与损伤脊髓的连通性。

Abstract:

Spinal cord injury (SCI) damages not only the gray matter neurons, but also the white matter axonal tracts that carry signals to and from the brain, resulting permanent loss of function below injury. Neural stem cells (NSCs) have high therapeutic potential for reconstruction of the injured spinal cord since they can potentially form neuronal relays to bridge functional connectivity between separated spinal cord segments. This requires host axonal regeneration into and connectivity with donor neurons, and axonal growth and connectivity of donor neurons to host central nervous system (CNS) circuitry. In this minireview, we will discuss key studies that explore novel neuronal relay formation by grafting NSCs in models of SCI, with emphasis on long-distance axonal growth and connectivity of NSCs grafted into injured spinal cord.