中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (3): 232-233.doi: 10.4103/1673-5374.128213

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

基因治疗促进视网膜神经节细胞轴突再生

  

  • 出版日期:2014-02-15 发布日期:2014-02-15

Gene therapy and the regeneration of retinal ganglion cell axons

  • Online:2014-02-15 Published:2014-02-15
  • Contact: Alan R. Harvey, Ph.D., Winthrop Professor, School of Anatomy, Physiology and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia, alan.harvey@uwa.edu.au.

摘要:

因受成熟神经元内源性因素及外源性因素的限制,成年哺乳类动物中枢神经系统损伤后再生能力非常有限。对中枢神经损伤的治疗不仅要维持受损神经元的存活,而且要促进轴突的远距离再生长,并形成原有的靶点结构。视网膜和视神经是中枢神经系统的一部分,视神经损伤模型常用来检测新方法能否促进再生。多数的眼科疾病都存在着中央投射神经元的丢失,因此,检测改善视网膜神经节细胞的存活能力具有直接的临床相关性。

Abstract:

Because the adult mammalian central nervous system (CNS) has only limited intrinsic capacity to regenerate connections after injury, due to factors both intrinsic and extrinsic to the mature neuron, therapies are required to support the survival of injured neurons and to promote the long-distance regrowth of axons back to their original target structures. The retina and optic nerve (ON) are part of the CNS and this system is much used in experiments designed to test new ways of promoting regeneration after injury. Testing of therapies designed to improve RGC viability also has direct clinical relevance because there is loss of these centrally projecting neurons in many ophthalmic diseases.