中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (3): 276-279.doi: 10.4103/1673-5374.128221

• 原著:退行性病与再生 • 上一篇    下一篇

深部脑刺激可引起难治性特发性帕金森病患者脑静脉血流改变:双倍剂量钆增强脑MRI评价

  

  • 收稿日期:2013-11-14 出版日期:2014-02-15 发布日期:2014-02-15

Vascular changes caused by deep brain stimulation using double-dose gadolinium-enhanced brain MRI

Byeong Sam Choi1, Yong Hwan Kim2, Sang Ryong Jeon3   

  1. 1 Department of Neurological Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
    2 Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN, USA
    3 Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • Received:2013-11-14 Online:2014-02-15 Published:2014-02-15
  • Contact: Sang Ryong Jeon, M.D., Ph.D., Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43gil, Songpa-gu, Seoul, Korea, srjeon@amc.seoul.kr.
  • Supported by:

    This work was supported by a KRCF National Agenda Project.

摘要:

我们对2007年1月至2011年5月进行阶段性双侧丘脑底核深部脑刺激的32例药物难治性特发性帕金森病病例资料进行回顾性分析。应用双倍剂量钆增强脑MRI对进行两次深部脑刺激治疗患者的脑血管系统进行检测。发现直窦、上矢状窦、丘脑支脑内静脉、前尾状核静脉尺寸均有所减小。结果表明双侧丘脑底核深部脑刺激影响脑静脉血流。

关键词: 神经再生, 钆增强脑MRI, 深部脑刺激, 丘脑底核, 脑血管系统, 直窦, 上矢状窦, 丘脑支脑内静脉, 前尾状核静脉, 韩国KRCF国家议程项目

Abstract:

We retrospectively analyzed the clinical data of 32 patients with medically intractable idiopathic Parkinson’s disease who had undergone staged bilateral deep brain stimulation of the subthalamic nuclei from January 2007 to May 2011. The vascularture of the patients who received two deep brain stimulations was detected using double-dose gadolinium-enhanced brain MRI. The dimensions of straight sinus, superior sagittal sinus, ipsilateral internal cerebral vein in the thalamic branch and ipsilateral anterior caudate vein were reduced. These findings demonstrate that bilateral deep brain stimulation of the subthalamic nuclei affects cerebral venous blood flow.

Key words: nerve regeneration, gadolinium-enhanced brain MRI, deep brain stimulation, subthalamic nuclei, vascularture, straight sinus, superior sagittal sinus, internal cerebral vein in the thalamic branch, anterior caudate vein, KRCF National Agenda Project, neural regeneration