1.Previous studies addressing the analgesic effect of acupuncture mainly focused on purine and a single purine receptor; no studies have examined the possible influence of synergism or antagonism with other receptors.
2.Electroacupuncture may induce an analgesic effect in neuropathic pain by influencing both purinergic A1 and P2X purinoceptor 3 (P2X3) receptors simultaneously.
3.Electroacupuncture analgesia may also involve adenosine and adenosine 5’-triphosphate disodium receptors in the peripheral and central nervous systems. Electroacupuncture can inhibit purinergic A1 and P2X3 receptors and exert an analgesic effect on neuropathic pain.
1.国内外对针刺镇痛与嘌呤类物质及其受体关系的研究,大多局限在单一物质及其受体的研究,目前尚无多受体相互协同或拮抗作用与针刺镇痛的研究。
2.文章分析了相关文献信息提出了针刺信号可能同时影响2种受体以起到镇痛效应的假设。
3.中枢和周围神经系统中腺苷和ATP受体均参与电针对神经性疼痛的镇痛过程,电针可能会同时抑制嘌呤A1和P2X3受体,对神经性疼痛产生镇痛作用。