中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (3): 329-336.doi: 10.4103/1673-5374.128232

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

参与中枢神经系统发育和损伤修复的Olig家族

  

  • 收稿日期:2013-11-15 出版日期:2014-02-15 发布日期:2014-02-15
  • 基金资助:

    国家自然科学基金资助项目(No.81171859);重庆自然科学基金项目(cstc2012jjA10058) ;重庆卫生局项目(2011-2-172).

The Olig family affects central nervous system development and disease

Botao Tan, Jing Yu, Ying Yin, Gongwei Jia, Wei Jiang, Lehua Yu   

  1. Department of Rehabilitation Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
  • Received:2013-11-15 Online:2014-02-15 Published:2014-02-15
  • Contact: Lehua Yu, M.D., Ph.D., Department of Rehabilitation Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China, yulehuadoc@aliyun.com.
  • Supported by:

    This study was supported by grants from the National Natural Science Foundation of China, No. 81171859; the Natural Science Foundation of Chongqing, No. cstc2012jjA10058; and the Chongqing Health Bureau Project, No. 2011-2-172.

摘要:

Olig家族已被证实对前体神经细胞向神经元与胶质细胞的分化方向的选择上具有重要作用,也广泛参与中枢神经系统的各种急慢性损伤的修复。因此,文章综述了Olig家族在中枢神经系统发育及损伤修复中的作用,旨在助于全面理解Olig家族在中枢神经系统发育和疾病中的作用,将为中枢神经系统损伤后的神经再生提供可能的作用靶点。

关键词: 神经再生, 综述, Olig, 少突胶质细胞, 星形胶质细胞, 中枢神经系统疾病, 脱髓鞘, 发育, 分化

Abstract:

Neural cell differentiation and maturation is a critical step during central nervous system development. The oligodendrocyte transcription family (Olig family) is known to be an important factor in regulating neural cell differentiation. Because of this, the Olig family also affects acute and chronic central nervous system diseases, including brain injury, multiple sclerosis, and even gliomas. Improved understanding about the functions of the Olig family in central nervous system development and disease will greatly aid novel breakthroughs in central nervous system diseases. This review investigates the role of the Olig family in central nervous system development and related diseases.

Key words: nerve regeneration, brain injury, spinal cord injury, review, Olig family, oligodendrocytes, astrocytes, central nervous system disease, demyelination, development, differentiation, NSFC grant, neural regeneration