中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (9): 924-930.doi: 10.4103/1673-5374.133141

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

大黄酚可减轻铅中毒仔鼠海马神经元的损伤

  

  • 收稿日期:2014-04-25 出版日期:2014-05-20 发布日期:2014-05-20
  • 基金资助:

    张家口科学技术委员会基金会的支持(1021098d),河北省卫生局医学科研项目(20100144)

Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice

Ji Zhang, Chunlin Yan, Shu Wang, Yong Hou, Guiping Xue, Li Zhang   

  1. Department of Pharmacology, Hebei North University, Zhangjiakou, Hebei Province, China
  • Received:2014-04-25 Online:2014-05-20 Published:2014-05-20
  • Contact: Shu Wang, Department of Pharmacology, Hebei North University, Zhangjiakou 075000, Hebei Province, China, shuwang388@163.com.
  • Supported by:

    This study was financially supported by the Science and Technology Commission Foundation of Zhangjiakou City, No. 1021098D, and the Medical Scientific Research Project of Health Bureau of Hebei Province, No. 20100144, and the Natural Science Foundation of Hebei Province, No. H2012405016, and the Innovative Talents Project of Hebei North University, No. CXRC1325, and the Major Projects of Hebei North University, No. ZD201310.

摘要:

以往研究表明大黄酚可以改善铅中毒造成的成年小鼠的学习记忆障碍,实验假设大黄酚对铅中毒仔鼠学习记忆障碍及海马神经元损伤具有改善作用。实验在铅中毒仔鼠模型哺乳期结束后将0.1, 1.0, 10.0 mg/kg大黄酚注射于腹腔后发现,大黄酚可显著减轻海马神经元损伤,提高铅中毒仔鼠的学习记忆能力,降低血清和脑、心、脾、肝、肾组织中的铅含量,提高脑、肝、肾组织中过氧化物歧酶和谷胱甘肽过氧化物酶活性,降低丙二醛含量,说明大黄酚可显著减轻铅中毒所致仔鼠海马神经元损伤程度。

Abstract:

Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol (0.1, 1.0, 10.0 mg/kg) was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.