中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (9): 919-923.doi: 10.4103/1673-5374.133133

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

骨髓间充质干细胞静脉移植促进脑创伤后的神经再生

  

  • 收稿日期:2014-03-20 出版日期:2014-05-20 发布日期:2014-05-20

Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury

Fatemeh Anbari 1, Mohammad Ali Khalili 1, Ahmad Reza Bahrami 2, Arezoo Khoradmehr 1, Fatemeh Sadeghian 1, Farzaneh Fesahat  1, Ali Nabi 1   

  1. 1 Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
    2 Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
  • Received:2014-03-20 Online:2014-05-20 Published:2014-05-20
  • Contact: Mohammad Ali Khalili, Ph.D., Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, khalili59@hotmail.com.
  • Supported by:

    This study was supported by research center from Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

摘要:

为观察静脉注射同种异体骨髓间充质干细胞对脑创伤大鼠大脑丢失神经细胞的补充作用,实验建立重物自由落体打击创伤性脑损伤Wistar大鼠模型,并给予其尾静脉注射3×106大鼠骨髓间充质干细胞。结果显示,细胞移植后14d,创伤性脑损伤大鼠损伤大脑皮质骨髓间充质干细胞分化为神经元和神经胶质样细胞,大鼠神经功能明显改善。说明骨髓间充质干细胞静脉移植可促进创伤性损伤大脑皮质神经细胞再生,从而成为已丢失神经细胞的有益补充。

关键词: 神经再生, 骨髓间充质干细胞, 创伤性脑损伤, 静脉注射, 细胞分化, 神经功能, 大脑皮质, 大鼠

Abstract:

To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells. 

Key words: nerve regeneration, bone marrow mesenchymal stem cells, traumatic brain injury,  , intravenous administration, cell differentiation, neurologic function, cerebral cortex, rats, neural  regeneration