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    Anti-inflammatory effect of miR-125a-5p on experimental optic neuritis by promoting the differentiation of Treg cells
  • Figure 7| Infiltration in the retina of EAE mice.

    The thickness of the GCL in the EAE group (10.48 ± 0.5103 μm) was significantly thinner than that in the normal control group (19.26 ± 2.077 μm, P = 0.0148). The thickness of the GCL in the overexpressed group (20.4 ± 1.898 μm) was significantly thicker than that in the corresponding control group (9.52 ± 0.3781 μm, P = 0.0049). There was no difference in the thickness of the GCL between the silenced (9.473 ± 0.8982 μm) and the corresponding control group (10.52 ± 0.9641 μm, P = 0.4695). These results indicated that MOG35-55 immunization led to the loss of retinal ganglion cells, and that overexpression of miR-125a-5p alleviated the loss. Silencing of miR-125a-5p did not further aggravate the loss (Figure 7).


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  • 发布日期: 2022-07-20  浏览: 177
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