神经退行性病

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis

• Figure 2｜Fasudil-modified macrophages decrease inflammation and promote myelination. 

  

  
  结果：The pathological changes that occur during EAE include demyelinating lesion formation and inflammatory cell infiltration, both of which are intimately correlated with disease progression when they develop in the CNS microenvironment. Thus, we observed neuroinflammation and spinal cord demyelination in the two groups. As shown in Figure 2A and B, injection with Fasudil-treated macrophages significantly inhibited inflammatory cell infiltration (P < 0.001; Figure 2A) and demyelination (P < 0.01; Figure 2B) compared with injection with PBS-treated macrophages. Furthermore, immunofluorescence staining showed that, in comparison with the PBS-Mφ group, infiltration of CD68+ macrophages was significantly decreased in the Fasudil-Mφ group (P < 0.01; Figure 2C). 
  
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发布日期： 2023-09-02  浏览： 134