神经退行性病
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Figure 8｜MgT-mediated protection against intestinal pathology and barrier dysfunction of APP/PS1 mice.
To investigate the effects of MgT on the intestinal pathology of APP/PS1 mice, we examined histopathological changes in the colon. H&E staining confirmed that the colonic mucosal epithelium of the WT group was intact, the intestinal glands were abundant and tightly arranged, goblet cells were abundant, and there were no evident abnormalities in cell morphology. In the APP/PS1 group, H&E staining revealed slight mucosal epithelial cell damage, hyperchromatic nuclear pyknosis, enhanced eosinophilia in the cytoplasm, and occasional slight inflammatory cell infiltration into the lamina propria. By contrast, in the MgT treatment group, the mucosal epithelium was intact, the intestinal glands were abundant and tightly arranged, goblet cells were abundant, and cell morphology was normal with no evident abnormalities (Figure 8A).
The levels of tight junction proteins were also determined to further examine the effects of MgT treatment on intestinal integrity. The colonic levels of ZO-1, occludin, and claudin-5 were significantly lower in APP/PS1 mice than in WT mice, but were significantly restored by MgT treatment (Figure 8B).
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