脑损伤
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Figure 7 ｜ BAM depletion improves tissue damage after acute stroke.
To investigate the effect of clodronate-containing liposomes on microglia, Iba1 staining of brain tissue was performed 24 hours post-surgery. The immunofluorescence images revealed the presence of microglia both with and without treatment, and no significant differences were observed between the groups. Therefore, it can be concluded that clodronate-containing liposomes primarily impact BAMs without significantly affecting the number of microglia (Figure 7A). Meanwhile, HE staining of the brain demonstrated relatively few inflammatory cells in the cerebral infarction area following treatment, indicating recovery (Figure 7B). Additionally, there were no significant differences in the number of inflammatory cells preset in the heart, liver, spleen, lungs, and kidneys before and after treatment (Figure 7C).