Carbenoxolone pretreatment and treatment of posttraumatic epilepsy

doi:10.3969/j.issn.1673-5374.2013.02.010

Abstract

Abstract:

Gap junction blocking agents can inhibit spontaneous discharge frequency in cells. We established a rat model of posttraumatic epilepsy induced using ferric ions. Rats were intraperitoneally injected with carbenoxolone, 20 mg/kg, prior to and 30 minutes after model establishment, once a day for 14 consecutive days. Immunohistochemistry showed glial cell proliferation around a cortical focus and significantly increased connexin expression in posttraumatic epilepsy. However, carbenoxolone pretreatment or treatment significantly reduced connexin expression in the cortex, inhibited glial fibrillary acidic protein expression and ameliorated seizure degree in rats. These findings indicate that large amounts of glial cell proliferation and abnormal gap junction generation play a role in posttraumatic epilepsy, and that carbenoxolone may prevent and treat this disease.

Key words: neural regeneration, brain injury, posttraumatic epilepsy, ferric ion, gap junction, carbenoxolone, glial fibrillary acidic protein, connexin 43, seizure, brain injury, grant-supported paper, photographs-containing paper, neuroregeneration

Weiguan Chen, Zhiwei Gao, Yaohui Ni, Zhenxiang Dai. Carbenoxolone pretreatment and treatment of posttraumatic epilepsy[J]. Neural Regeneration Research, 2013, 8(2): 169-176.

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