Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (3): 329-336.doi: 10.4103/1673-5374.128232

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The Olig family affects central nervous system development and disease

Botao Tan, Jing Yu, Ying Yin, Gongwei Jia, Wei Jiang, Lehua Yu   

  1. Department of Rehabilitation Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
  • Received:2013-11-15 Online:2014-02-15 Published:2014-02-15
  • Contact: Lehua Yu, M.D., Ph.D., Department of Rehabilitation Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China, yulehuadoc@aliyun.com.
  • Supported by:

    This study was supported by grants from the National Natural Science Foundation of China, No. 81171859; the Natural Science Foundation of Chongqing, No. cstc2012jjA10058; and the Chongqing Health Bureau Project, No. 2011-2-172.

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Abstract:

Neural cell differentiation and maturation is a critical step during central nervous system development. The oligodendrocyte transcription family (Olig family) is known to be an important factor in regulating neural cell differentiation. Because of this, the Olig family also affects acute and chronic central nervous system diseases, including brain injury, multiple sclerosis, and even gliomas. Improved understanding about the functions of the Olig family in central nervous system development and disease will greatly aid novel breakthroughs in central nervous system diseases. This review investigates the role of the Olig family in central nervous system development and related diseases.

Key words: nerve regeneration, brain injury, spinal cord injury, review, Olig family, oligodendrocytes, astrocytes, central nervous system disease, demyelination, development, differentiation, NSFC grant, neural regeneration