Neural Regeneration Research ›› 2015, Vol. 10 ›› Issue (8): 1305-1311.doi: 10.4103/1673-5374.162765

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Propofol promotes spinal cord injury repair by bone marrow mesenchymal stem cell transplantation

Ya-jing Zhou1, Jian-min Liu2, Shu-ming Wei3, Yun-hao Zhang1, Zhen-hua Qu1, Shu-bo Chen4   

  1. 1 Department of Anesthesiology, Xingtai People’s Hospital, Hebei Medical University, Xingtai, Hebei Province, China
    2 Department of Orthopedic Trauma, Xingtai People’s Hospital, Hebei Medical University, Xingtai, Hebei Province, China
    3 Department of Anesthesiology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
    4 Department of Urinary Surgery, Xingtai People’s Hospital, Hebei Medical University, Xingtai, Hebei Province, China
  • Received:2015-06-03 Online:2015-08-24 Published:2015-08-24
  • Contact: Shu-bo Chen, baidong_2@163.com.

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Abstract:

Propofol is a neuroprotective anesthetic. Whether propofol can promote spinal cord injury repair by bone marrow mesenchymal stem cells remains poorly understood. We used rats to investigate spinal cord injury repair using bone marrow mesenchymal stem cell transplantation combined with propofol administration via the tail vein. Rat spinal cord injury was clearly alleviated; a large number of newborn non-myelinated and myelinated nerve fibers appeared in the spinal cord, the numbers of CM-Dil-labeled bone marrow mesenchymal stem cells and fluorogold-labeled nerve fibers were increased and hindlimb motor function of spinal cord-injured rats was markedly improved. These improvements were more prominent in rats subjected to bone marrow mesenchymal cell transplantation combined with propofol administration than in rats receiving monotherapy. These results indicate that propofol can enhance the therapeutic effects of bone marrow mesenchymal stem cell transplantation on spinal cord injury in rats.

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