Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (1): 6-11.doi: 10.4103/1673-5374.286954

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Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke

Wan Zhang1, #, Tian Tian2, #, Shao-Xin Gong3, Wen-Qian Huang1, Qin-Yi Zhou1, Ai-Ping Wang1, *, Ying Tian1, *#br#   

  1. 1 Institute of Clinical Research, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan Province, China; 2 Department of Clinical Laboratory, the First Hospital of Changsha, Changsha, Hunan Province, China;   3 Department of Pathology, the First Affiliated Hospital of University of South China, Hengyang, Hunan Province, China
  • Online:2021-01-15 Published:2020-11-23
  • Contact: Ai-Ping Wang, waiping2011@163.com; Ying Tian, uscty@163.com. #Both authors contributed equally to the work.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 31871169, 81600040 ; Key Project of Department of Education of Hunan Province, China, No. 18A243; Innovation Guidance Project of Hunan Province, China, No. 2018SK51606 ; the Natural Science Foundation of Hunan Province of China, No. 2017JJ3279.

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Abstract: Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke. Microglial activation and polarization, and the inflammatory response mediated by these cells play important roles in the development, progression and outcome of brain injury after ischemic stroke. Currently, there is no effective strategy for treating ischemic stroke in clinical practice. Therefore, it is clinically important to study the role and regulation of microglia in stroke. In this review, we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke, with the aim of providing a better understanding of the relationship between ischemic stroke and microglia.

Key words: brain, cells, central nervous system, inflammation, injury, macrophages, repair, review, stroke