Abstract: Neurotrophic factors are growth factors that can nourish neurons and promote neuron survival and regeneration. Dental origin mesenchymal stem cells express various neurotrophic factors during tooth development and the expression level changes during cell differentiation. Dental origin stem cells are reported to mediate neuronal tissue repair by increasing the secretion of neurotrophic factors. On the other hand, neurotrophic factors promote survival, proliferation, angiogenesis, migration and neuron - like differentiation in dental origin stem cells, which can be applied to the dental clinic. The prospective emphasizes the connection of the dental pulp stem cells and nervous system through neurotrophic factors.