Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (2): 338-340.doi: 10.4103/1673-5374.317974
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Daniel Terheyden-Keighley, Marco Leibinger, Dietmar Fischer*
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Abstract: We recently achieved significant functional recovery after a complete spinal cord injury, allowing previously paralyzed mice to walk again. This was accomplished by a single, unilateral application of an adeno-associated virus (AAV) carrying the cDNA for the designer cytokine hyper-interleukin-6 (hIL-6) into the sensorimotor cortex after spinal cord injury. This treatment resulted in the transneuronal delivery of the designer cytokine to neurons in subcortical locomotor centers, axon regeneration of cortical- and serotonergic neurons across the lesion site, and functional recovery of hindlimb stepping. Here we briefly cover the historical context, current implications, and future perspectives surrounding this new achievement.
Daniel Terheyden-Keighley, Marco Leibinger, Dietmar Fischer. Transneuronal delivery of designer cytokines: perspectives for spinal cord injury[J]. Neural Regeneration Research, 2022, 17(2): 338-340.
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URL: https://www.sjzsyj.com.cn/EN/10.4103/1673-5374.317974
https://www.sjzsyj.com.cn/EN/Y2022/V17/I2/338