Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (4): 245-250.

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Effects of lateral ventricular transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene on cognition in a rat model of Alzheimer’s disease

Ping Zhang1, Gangyong Zhao2, Xianjiang Kang3, Likai Su1   

  1. 1 Department of Neurology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
    2 Research Center for Bioengineering Technology, Hebei University, Baoding 071000, Hebei Province, China
    3 College of Life Science, Hebei University, Baoding 071000, Hebei Province, China
  • Received:2011-09-24 Revised:2011-12-22 Online:2012-02-05 Published:2012-02-05
  • Contact: Ping Zhang, Department of Neurology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China zhangpingbd@sina.com
  • About author:Ping Zhang☆, Doctor, Chief physician, Department of Neurology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China

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Abstract:

In the present study, transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene into the lateral ventricle of a rat model of Alzheimer’s disease, resulted in significant attenuation of nerve cell damage in the hippocampal CA1 region. Furthermore, brain-derived neurotrophic factor and tyrosine kinase B mRNA and protein levels were significantly increased, and learning and memory were significantly improved. Results indicate that transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene can significantly improve cognitive function in a rat model of Alzheimer’s disease, possibly by increasing the levels of brain-derived neurotrophic factor and tyrosine kinase B in the hippocampus.

Key words: Alzheimer’s disease, bone marrow-derived mesenchymal stem cells, brain-derived neurotrophic factor, lateral ventricle, electrotransfection, neural regeneration