Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (2): 309-310.doi: 10.4103/1673-5374.343904

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Approaches to quantify axonal morphology for the analysis of axonal degeneration

Alex Palumbo, Marietta Zille*   

  1. Department of Neurobiology, Harvard Medical School; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA 
    (Palumbo A)
    Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Vienna, Austria (Zille M)
  • Online:2023-02-15 Published:2022-08-05
  • Contact: Marietta Zille, PhD, marietta.zille@univie.ac.at.
  • Supported by:
    This work was funded by the Fraunhofer Society, grant number 600199, and by Joachim Herz Stiftung, grant number 850022 to MZ.

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Abstract: Morphological hallmarks of axonal degeneration (AxD): Axons transmit signals from one neuron to another and are crucial for the proper communication in the nervous system. Therefore, the disintegration of axons, a process named AxD, has detrimental consequences and plays a key role in many neurological diseases.