Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (36): 2860-2866.

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Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer’s disease

Xi Li1, Ming Li1, Yuan Li2, Qiankun Quan3, Juan Wang4   

  1. 1 Department of Geriatrics, Second Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
    2 Department of Encephalopathy, Xi’an Electric Power Central Hospital, Xi’an 710032, Shaanxi Province, China
    3 Research Center of Rehabilitation Science and Technology, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049,Shaanxi Province, China
    4 Department of Laboratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
  • Received:2012-06-14 Revised:2012-09-20 Online:2012-12-25 Published:2012-12-25
  • Contact: Department of Geriatrics,Second Affiliated Hospital,College of Medicine, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province,China lixi2100@sohu.com
  • About author:Xi Li☆, M.D., Master’s supervisor, Professor,Department of Geriatrics,Second Affiliated Hospital,College of Medicine, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province,China

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Abstract:

Ginsenoside Rg1 inhibits oxidation, aging and cell apoptosis, and improves cognitive function. In this study, we pretreated rat brain tissue sections with ginsenoside Rg1, and established brain slice models of Alzheimer’s disease induced by okadaic acid. The results revealed that ginsenoside Rg1 pretreatment suppressed the increase in phosphorylated Tau protein expression induced by incubation with okadaic acid, and reduced brain-derived neurotrophic factor expression. These results suggest that ginsenoside Rg1 upregulates brain-derived neurotrophic factor expression and inhibits Tau protein phosphorylation in brain slices from a rat model of Alzheimer’s disease.

Key words: Alzheimer’s disease, ginsenoside Rg1, okadaic acid, phosphorylated Tau protein, brain-derived neurotrophic factor, traditional Chinese medicine, neural regeneration