中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (18): 1721-1726.doi: 10.3969/j.issn.1673-5374.2013.18.010

• 原著:神经损伤修复保护与再生 • 上一篇    

慢性束缚应激大鼠下丘脑弓状核神经肽Y和瘦素受体的变化

  

  • 收稿日期:2012-10-22 修回日期:2013-02-12 出版日期:2013-06-25 发布日期:2013-06-25

Neuropeptide Y and leptin receptor expression in the hypothalamus of rats with chronic immobilization stress

Shaoxian Wang1, 2, Jiaxu Chen1, Guangxin Yue3, Minghua Bai1, Meijing Kou1, Zhongye Jin1   

  1. 1 School of Pre-clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
    2 Traditional Chinese Medicine College of Hebei Medical University, Shijiazhang 050000, Hebei Province, China
    3 Institute of Basic Theory in Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2012-10-22 Revised:2013-02-12 Online:2013-06-25 Published:2013-06-25
  • Contact: Jiaxu Chen, Ph.D., Professor, School of Pre-clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China, chenjx@ bucm.edu.cn
  • About author:Shaoxian Wang☆, M.D., Lecturer.

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摘要：

通过固定大鼠3h/d，连续21d建立慢性束缚应激大鼠模型，见其体质量和食物摄入量明显下降，免疫荧光双标方法检测到下丘脑弓状核中瘦素受体表达及两者共表达增加，而神经肽Y神经元数量下降。提示由于慢性束缚应激可能导致瘦素受体高表达，抑制神经肽Y的合成和分泌，从而打乱了下丘脑弓状核中摄食相关神经通路的平衡，发挥降低大鼠体质量和食物摄入量的作用。

关键词: 神经再生, 慢性束缚应激, 下丘脑, 弓状核, 免疫荧光双标, 神经肽Y, 瘦素受体, 摄食中枢, 体质量, 基金资助文章

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