中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (20): 1872-1880.doi: 10.3969/j.issn.1673-5374.2013.20.006

• 原著:神经损伤修复保护与再生 • 上一篇    下一篇

高脂饮食为何能诱发孕鼠子痫前期样改变？

  

  • 收稿日期:2013-04-05 修回日期:2013-06-06 出版日期:2013-07-15 发布日期:2013-07-15

Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?

Jing Ge1, 2, Jun Wang2, Dan Xue3, Zhengsheng Zhu4, Zhenyu Chen3, Xiaoqiu Li2, Dongfeng Su5, Juan Du1   

  1. 1 Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
    2 The General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China
    3 Department of Gynecology and Obstetrics, People’s Liberation Army No. 202 Hosiptal, Shenyang 110003, Liaoning Province, China
    4 Dantu District Sanitary Supervision Institute, Zhenjiang 212001, Jiangsu Provicne, China
    5 Department of Neurology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China
  • Received:2013-04-05 Revised:2013-06-06 Online:2013-07-15 Published:2013-07-15
  • Contact: Juan Du, Doctor’s supervisor, Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China, jingzicat@sina.com.
  • About author:Jing Ge, Ph.D., Associate chief physician. Jing Ge and Jun Wang contributed equally to this article.
  • Supported by:

    全军医学科技研究“十二五"面上项目（CWS11J003）

PDF

877

摘要：

在妊娠子痫前期-子痫的发病中致痫样发作的病因中脑组织神经递质水平的变化起到了非常重要的作用。由此假设，兴奋性神经递质谷氨酸的代谢型受体1可能参与脂质代谢紊乱致妊娠子痫前期的发病。我们以高脂饲料喂饲妊娠大鼠20d。成功诱导孕鼠产生高血压、蛋白尿等子痫前期样改变。同时，高脂饲料还使孕鼠海马代谢型谷氨酸受体1mRNA和蛋白的表达上调。说明孕鼠海马代谢型谷氨酸受体1表达上调对高脂饮食致妊娠子痫前期的发生起促进作用。

关键词: 神经再生, 基础实验, 子痫前期, 子痫, 兴奋性神经递质, 神经毒性, 高脂血症, 高血压, 妊娠, 脂蛋白相关磷脂酶A2, 代谢型谷氨酸受体1, 基金资助文章

Abstract:

Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as hyper-tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein ex-pressions were upregulated in the rat hippocampus. These findings indicate that increased expres-sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.

Key words: neural regeneration, preeclampsia, eclampsia, excitatory neurotransmitter, neurotoxicity, hyper-lipidemia, hypertension, pregnancy, lipoprotein-associated phospholipase A2, metabotropic gluta-mate receptor 1, grants-supported paper, neuroregeneration