中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (28): 2641-2648.doi: 10.3969/j.issn.1673-5374.2013.28.006

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

正交设计筛选针刺内关穴治疗脑梗死的最佳参数

  

  • 收稿日期:2013-02-02 修回日期:2013-09-02 出版日期:2013-10-05 发布日期:2013-10-05
  • 基金资助:

    国家重点基础研究发展计划（973 计划项目）（2012CB518505，2010CB530500，2006CB504504）

Orthogonal design to sift the optimal parameter of Neiguan acupuncture for cerebral infarction

Yanan Zhang1, Sha Yang2, 3, 4, Xiaonong Fan2, 3, 4, 5, Shu Wang2, 3, 4, Nina He6, Lingxin Li7, Ding Luo8, Xuemin Shi1   

  1. 1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    2 Acupuncture and Moxibustion Research Institute of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    3 Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine, Tianjin 300193, China
    4 Tianjin Key Laboratory of Acupuncture & Moxibustion Science, Tianjin 300193, China
    5 Three-level Laboratory of Acupuncture Dose-Effect Relationship, State Administration of Traditional Chinese Medicine, Tianjin 300193, China
    6 Wuhai Hospital of Traditional Chinese Medicine, Wuhai 016000, Inner Mongolia Autonomous Region, China
    7 Department of Rehabilitation Medicine, West China Medical School, West China Hospital Sichuan University, Chengdu 610041, Sichuan Province, China
    8 Postgraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2013-02-02 Revised:2013-09-02 Online:2013-10-05 Published:2013-10-05
  • Contact: Shu Wang, M.D., Professor, Chief physician, Acupuncture and Moxibustion Research Institute of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin Key Laboratory of Acupuncture & Moxibustion Science, Tianjin 300193, China, wangs2008@163.com.
  • About author:Yanan Zhang, M.D.
  • Supported by:

    This project was funded by Development Plan (973 Plan) of National Critical and Basic Research, No. 2012CB518505, 2010CB 530500, 2006CB504504.

PDF

1453

摘要：

针刺手法的个体差异性和不可复制性是制约针灸发展的瓶颈，也是影响经穴效应的关键因素。实验首次运用课题研制的针刺提插手法控制仪，用针刺内关穴的频率60，120，180次/min和持续时间5，60，180s正交组合构成的不同参数刺激内关穴(PC6)治疗大鼠大脑中动脉梗死模型。正交统计结果显示运用提插频率60次/min，针刺持续时间180s或者提插频率120/180次/min，针刺持续时间5/60s方式针刺内关穴对于提高脑梗死大鼠脑血流量及降低脑梗死体积的作用最显著；针刺频率和时间的交互作用是影响提插针刺法的关键因素。

关键词: 神经再生, 针灸, 量化针刺, 内关穴, 大脑中动脉梗死, 提插方法, 正交设计, 提插频率, 针刺持续时间, 基金资助文章

Abstract:

The individual difference and non-repeatability in acupuncture have not only restricted the devel-opment of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan (PC6) with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery. Results showed that stimulation at Neiguan with a frequency of 1 Hz and long duration of 180 seconds or 2/3 Hz and long duration of 5/60 se-conds significantly increased cerebral blood flow and decreased the ratio of infarct volume. Interac-tions between frequency and duration play a critical role in quantified acupuncture therapy.

Key words: neural regeneration, acupoint, quantified acupuncture, Neiguan, middle artery occlusion injury, lift-ing and thrusting method, orthogonal design, lifting and thrusting frequency, acupuncture duration, grants-supported paper, neuroregeneration